LncRNA PCGEM1 enhances metastasis and gastric cancer invasion through targeting of miR-129-5p to regulate P4HA2 expression.

CONCLUSION: These findings found that an over-expression of PCGEM1 in GC acts as a miR-129-5p sponge, leading to higher levels of P4HA2. The PCGEM1/miR-129-5p/P4HA2 axis was confirmed to possess a crucial role in GC metastasis and invasion, suggesting its utility as a potential diagnostic and therapeutic biomarker.
PMID: 32622013 [PubMed - as supplied by publisher]

Source: Experimental and Molecular Pathology - June 30, 2020 Category: Pathology Authors: Zhang T, Piao HY, Guo S, Zhao Y, Wang Y, Zheng ZC, Zhang J Tags: Exp Mol Pathol Source Type: research