Cancers, Vol. 12, Pages 1808: Genomic and Transcriptomic Characterisation of Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer
Cancers, Vol. 12, Pages 1808: Genomic and Transcriptomic Characterisation of Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer
Cancers doi: 10.3390/cancers12071808
Authors:
Sinead Toomey
Jillian Gunther
Aoife Carr
David C. Weksberg
Valentina Thomas
Manuela Salvucci
Orna Bacon
El-Masry Sherif
Joanna Fay
Elaine W. Kay
Katherine M. Sheehan
Deborah A. McNamara
Keith L Sanders
Geena Mathew
Oscar S. Breathnach
Liam Grogan
Patrick G. Morris
Wai C. Foo
Yi-Qian N. You
Jochen H. Prehn
Brian O’Neill
Sunil Krishnan
Bryan T. Hennessy
Simon J. Furney
Standard treatment for locally advanced rectal cancer (LARC) is neoadjuvant chemoradiotherapy (NACRT), followed by surgical resection. However, >70% of patients do not achieve a complete pathological response and have higher rates of relapse and death. There are no validated pre- or on-treatment factors that predict response to NACRT besides tumour stage and size. We characterised the response of 33 LARC patients to NACRT, collected tumour samples from patients prior to, during and after NACRT, and performed whole exome, transcriptome and high-depth targeted sequencing. The pre-treatment LARC genome was not predictive of response to NACRT. However, in line with the increasing recognition of microbial influence in cancer, RNA analysis of pre-treatment tumours suggested a greater abundance of Fusobacteria in intermediate and poor responders. In addition,...
Source: Cancers - Category: Cancer & Oncology Authors: Sinead Toomey Jillian Gunther Aoife Carr David C. Weksberg Valentina Thomas Manuela Salvucci Orna Bacon El-Masry Sherif Joanna Fay Elaine W. Kay Katherine M. Sheehan Deborah A. McNamara Keith L Sanders Geena Mathew Oscar S. Breathnach Liam Grogan Patrick Tags: Article Source Type: research