New guideline: Don't routinely screen for EAC in patients with chronic GERD

(Canadian Medical Association Journal) A new guideline from the Canadian Task Force on Preventive Health Care, based on a rigorous systematic review of the latest evidence, found no benefit of routine screening for esophageal adenocarcinoma (EAC) and precursor conditions (Barrett esophagus and dysplasia) in patients with chronic gastroesophageal reflux disease (GERD). The guideline, published in CMAJ (Canadian Medical Association Journal), recommends physicians in Canada continue current practice to not screen routinely
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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xel Maximilian Hillmer Esophageal adenocarcinoma (EAC) is a deadly disease with limited options for targeted therapy. With the help of next-generation sequencing studies over the last decade, we gained an understanding of the genomic architecture of EAC. The tumor suppressor gene TP53 is mutated in 70 to 80% of tumors followed by genomic alterations in CDKN2A, KRAS, ERBB2, ARID1A, SMAD4 and a long tail of less frequently mutated genes. EAC is characterized by a high burden of point mutations and genomic rearrangements, resulting in amplifications and deletions of genomic regions. The genomic complexity is likely hamper...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
ConclusionsMost current risk prediction models of esophageal cancer have a high ROB. Prediction models need further improvement in their quality and applicability to benefit esophageal cancer screening.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: REVIEW Source Type: research
In this study, we investigated the acid susceptibility in a Barrett’s cell culture in vitro model, using six cell lines, derived from squamous epithelium (EPC1 and EPC2), metaplasia (CP-A), dysplasia (CP-B), and EAC (OE33 and OE19) cells. Cells exposed to acidic pH showed a decreased viability dependent on time, pH, and progression status in the Barrett’s sequence, with the highest acid susceptibility in the squamous epithelium (EPC1 and EPC2), and the lowest in EAC cells. Acid pulsing was accompanied with an activation of the Nrf2/Keap1- and the NFκB-pathway, resulting in an increased expression of HO1&m...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Oesophageal adenocarcinoma (OAC) is a lethal cancer with a rising incidence globally [1]. Although oesophageal squamous cell carcinoma (OSCC) remains the dominant subtype worldwide due to its predominance across the “oesophageal cancer belt” through China, Central Asia, and Northern Iran as well as Eastern Africa, the incidence of OAC is rising in these populations also [2, 3]. The main risk factors for OAC include advancing age, male sex, obesity, and gastro-oesophageal reflux disease (GORD), and changes i n these epidemiological risk factors across both Western populations and through the oesophageal cancer b...
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Tumour Review Source Type: research
People who find themselves reaching for antacid several times a month, might consider reaching out to their doctor instead. Gastroesophageal reflux disease (GERD), the same condition that causes heartburn, is also linked to a deadly form of esophageal cancer, adenocarcinoma. Lack of awareness about the link between reflux and cancer has contributed to a 733 […]Find jobs at  Careers by  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
Esophageal adenocarcinoma (EAC) represents an exemplar of obesity-associated carcinogenesis, with a progressive increase in EAC risk with increased body mass index. In this context, there is increased focus on visceral adipose tissue and associated metabolic dysfunction, including hypertension, diabetes mellitus and hyperlipidemia, or combinations of these in the metabolic syndrome. Visceral obesity (VO) may promote EAC via both directly impacting on gastro-esophageal reflux disease and Barrett's esophagus, as well as via reflux-independent effects, involving adipokines, growth factors, insulin resistance, and the microbio...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
South Med J. 2021 Mar;114(3):161-168. doi: 10.14423/SMJ.0000000000001226.ABSTRACTThe incidence of esophageal cancer (EC) is on the rise. With the distinct subtypes of adenocarcinoma and squamous cell carcinoma comes specific risk factors, and as a result, people of certain regions of the world can be more prone to a subtype. For example, squamous cell carcinoma of the esophagus has the highest incidence in eastern Africa and eastern Asia, with smoking being a major risk factor, whereas adenocarcinoma is more prevalent in North America and western Europe, with gastroesophageal reflux disease being a leading risk factor. Wit...
Source: Southern Medical Journal - Category: General Medicine Authors: Source Type: research
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