Dose Investigation of Imrecoxib in Patients with Renal Insufficiency Based on Modelling and Simulation.

Conclusion A PPK model of imrecoxib and its two metabolites is presented. The renal insufficiency regimen should be reduced to '75 mg q12h' or '50 mg q8h'.
PMID: 32621967 [PubMed - as supplied by publisher]

Source: European Journal of Pharmaceutical Sciences - June 30, 2020 Category: Drugs & Pharmacology Authors: Li Y, Wang J, Huang J, Yu J, Wang Y, Tan H, Zhang H, Yang G, Pei Q Tags: Eur J Pharm Sci Source Type: research