Corticosteroid Injections May Increase Retear and Revision Rates of Rotator Cuff Repair: A Systematic Review
To synthesize the clinical outcome data of preoperative and postoperative corticosteroid injections (CIs) and their effect on rotator cuff repairs (RCRs).
Glucocorticoids (GCs) and the glucocorticoid receptor (GR) are important regulators of development, inflammation, stress response and metabolism, demonstrated in various diseases including Addison's disease, Cushing's syndrome and by the many side effects of prolonged clinical administration of GCs. These conditions include severe metabolic challenges in key metabolic organs like the liver. In the liver, GR is known to regulate the transcription of key enzymes in glucose and lipid metabolism and contribute to the regulation of circadian-expressed genes. Insights to the modes of GR regulation and the underlying functional m...
Dalton Trans., 2020, Accepted Manuscript DOI: 10.1039/D0DT02985H, PaperAllan G Blackman, Elaine Schenk, Rebecca Jelley, Elizabeth Krenske, Lawrence Gahan The τ5 parameter, first proposed by Addison and coworkers, is the principal measure of the geometry of five-coordinate transition metal complexes, with τ5 = 0 said to describe a perfect... The content of this RSS Feed (c) The Royal Society of Chemistry
ConclusionHealthcare utilization and costs of prolactinoma patients are related to patient-reported HRQoL, bother by disease and needs for support. Therefore, addressing patients ’ HRQoL and needs is a way forward to improve efficiency of care and patients’ health status.
In this study, MR images from 4 new patients and additional published case reports were reviewed by a pediatric neuroradiologist. Analysis reveals recurring patterns of features in affected patients, including isolated callosal dysgenesis and prominent involvement of the globus pallidus, thalamus, and dentate nucleus, with progressive atrophy and worsening of brain lesions. MR imaging findings of abnormal deep gray nuclei, microcephaly, or callosal dysgenesis in an infant or young child exhibiting other typical clinical features of sphingosine-1-phosphate lyase insufficiency syndrome should trigger prompt genetic testing for SGPL1 mutations.
Hypertonic saline (HTS) infusions have been a standard treatment modality for patients with traumatic brain injury to reduce intracranial swelling and elevated intracranial pressures. Although traditionally titrated by providers, emerging evidence supports nurse driven protocols, similar to management of other high-risk medications such as heparin infusions. Given the lack of studies validating nurse driven to provider driven HTS protocols we sought to directly compare outcomes of a nurse driven protocol.
Emergency general surgery (EGS) patients have increased risk of mortality compared with their elective counterparts, and a large amount of work has recently been performed on this topic using national billing data. Therefore, the aim of this study is to examine risk factors for mortality in a large regional EGS dataset which included both administrative and clinical data points. We hypothesized that many important risk factors for mortality are clinical datapoints only available via electronic medical record (EMR).
Journal of Chemical Information and ModelingDOI: 10.1021/acs.jcim.0c00725
Authors: Ntali G, Tsagarakis S Abstract INTRODUCTION: Pituitary gland is vulnerable to traumatic brain injury (TBI). As a result a series of neuroendocrine changes appear after head injury; in many occasions they reverse with time, while occasionally new late onset changes may develop. AREAS COVERED: In this review, we focus on the prevalence of anterior and posterior pituitary hormonal changes in the acute and chronic post-TBI period in both children and adults. Moreover, we present evidence supporting the need for evaluating pituitary function along with the current suggestions for the most appropriate screen...
The objective of the study was to evaluate associations among diet quality, serum uremic toxin concentrations, and the gut microbiota profile in adults undergoing hemodialysis therapy.
Authors: Heshmatzad K, Mahdieh N, Rabbani A, Didban A, Rabbani B Abstract Familial glucocorticoid deficiency is a rare autosomal recessive genetic disorder which belongs to a group of primary adrenal insufficiency (PAI) and is mainly caused by mutations in the MC2R and MRAP genes. A comprehensive search was conducted to find the reported variants of MC2R and MRAP genes. In silico pathogenic analysis was performed for the reported variants. PCR amplification and sequencing were performed for three patients. Structural analysis, modeling, and interactome analysis were applied to characterize novel MC2R variants and t...