Cancers, Vol. 12, Pages 1799: Comprehensive Constitutional Genetic and Epigenetic Characterization of Lynch-Like Individuals

In conclusion, the use of an ad-hoc designed gene panel combined with pathogenicity assessment of variants allowed the identification of deleterious MMR mutations as well as new LLS candidate causal genes. Constitutional epimutations in non-LS-associated genes are not responsible for LLS.

Source: Cancers - July 4, 2020 Category: Cancer & Oncology Authors: Estela D ámaso Maribel Gonz ález-Acosta Gardenia Vargas-Parra Matilde Navarro Judith Balma ña Teresa Ramon y Cajal Noem í Tuset Bryony A. Thompson F átima Marín Anna Fern ández Carolina G ómez Àngela Velasco Ares Solanes S ílvia Iglesias Gisel Tags: Article Source Type: research