Molecules, Vol. 25, Pages 3064: Standardized Extract of Atractylodis Rhizoma Alba and Fructus Schisandrae Ameliorates Coughing and Increases Expectoration of Phlegm
Molecules, Vol. 25, Pages 3064: Standardized Extract of Atractylodis Rhizoma Alba and Fructus Schisandrae Ameliorates Coughing and Increases Expectoration of Phlegm
Molecules doi: 10.3390/molecules25133064
Authors:
Hee-Sung Chae
Sun Young Kim
Pisey Pel
Jungmoo Huh
Sun-Woo Joo
Yun Young Lim
Shin Jung Park
Jong Lae Lim
Young-Won Chin
Cough and phlegm frequently occur in respiratory diseases like upper respiratory tract infections, acute bronchitis, and chronic obstructive pulmonary diseases. To relieve these symptoms and diseases, various ingredients are being used despite the debates on their clinical efficacy. We aimed to investigate the effects of the extract CKD-497, composed of Atractylodis Rhizoma Alba and Fructus Schisandrae, in relieving cough and facilitating expectoration of phlegm. CKD-497 was found to inhibit inflammatory mediators such as interleukin-8 (IL-8) and tumor necrosis factor α (TNF-α) in lipopolysaccharide (LPS)-treated mouse macrophages and transient receptor potential cation channel 1 (TRPV-1)-overexpressed human bronchial epithelial cells stimulated by capsaicin. CKD-497 decreased the viscosity of the mucin solution. During in vivo experiments, CKD-497 reduced coughing numbers and increased expectoration of phlegm via mucociliary clearance enhancement. Collectively, these data suggest that CKD-497 possesses potential for cough and phlegm expectoration treatment.
Source: Molecules - Category: Chemistry Authors: Hee-Sung Chae Sun Young Kim Pisey Pel Jungmoo Huh Sun-Woo Joo Yun Young Lim Shin Jung Park Jong Lae Lim Young-Won Chin Tags: Article Source Type: research
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