Neonatal neuroimaging and neurophysiology predict infantile onset epilepsy after perinatal hypoxic ischemic encephalopathy

Hypoxic-ischemic encephalopathy (HIE) due to perinatal asphyxia occurs in approximately 2,5 per 1000 live full-term births [1], and is one of the leading causes of neonatal deaths and severe developmental and neurological compromise [2]. HIE is also one of the most common causes of infantile spasms syndrome (IS) [3] accounting for 8-10% of all IS cases [4,5]. HIE is currently treated with therapeutic hypothermia, which despite its favorable effect on the overall outcome, does not affect the rate of postneonatal epilepsy [6 –8] or IS [9].

Source: Seizure: European Journal of Epilepsy - July 2, 2020 Category: Neurology Authors: P äivi Nevalainen, Marjo Metsäranta, Sanna Toiviainen-Salo, Viviana Marchi, Kirsi Mikkonen, Sampsa Vanhatalo, Leena Lauronen Source Type: research