HIV-1 Virologic Rebound Due to Coadministration of Divalent Cations and Bictegravir

In this report we present a patient taking bictegravir/emtricitabine/tenofovir alafenamide who became viremic after ingesting zinc and calcium supplements and later was able to obtain virologic re-suppression after discontinuing supplements. This case represents a potential significant drug interaction between a commonly prescribed antiretroviral drug class and readily available over-the-counter divalent cation products.

http://link.springer.com/10.1007/s40121-020-00307-4

Source: Infectious Diseases and Therapy - July 3, 2020 Category: Infectious Diseases Source Type: research