Nobiletin selectively inhibits oral cancer cell growth by promoting apoptosis and DNA damage in vitro
Publication date: Available online 4 July 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Junjun Yang, Yang yang, Lu Wang, Qiuchen Jin, Minghui Pan
Publication date: Available online 11 August 2020Source: Journal of Oral BiosciencesAuthor(s): Sho Akashi, Takashi Nishida, Tomomi Mizukawa, Kazumi Kawata, Masaharu Takigawa, Seiji Iida, Satoshi Kubota
Cachexia, a devastating wasting syndrome characterized by severe weight loss with specific losses of muscle and adipose tissue, is driven by reduced food intake, increased energy expenditure, excess catabolism, and inflammation. Cachexia is associated with poor prognosis and high mortality and frequently occurs in patients with cancer, chronic kidney disease, infection, and many other illnesses. There is no effective treatment for this condition. Hypothalamic melanocortins have a potent and long-lasting inhibitory effect on feeding and anabolism, and pathophysiological processes increase melanocortin signaling tone, leadin...
Authors: Wu G Abstract Sense organs (eyes, ears, nose, tongue, and skin) provide senses of sight, hearing, smell, taste, and touch, respectively, to aid the survival, development, learning, and adaptation of humans and other animals (including fish). Amino acids (AAs) play an important role in the growth, development, and functions of the sense organs. Recent work has identified receptor-mediated mechanisms responsible for the chemosensory transduction of five basic taste qualities (sweet, sour, bitter, umami and salty tastes). Abnormal metabolism of AAs result in a structural deformity of tissues and their dysfunc...
CONCLUSIONS: It is important to know the early withdrawal syndrome to assess the ideal treatment. We propose a personal protocol to present this complication. PMID: 32773739 [PubMed - as supplied by publisher]
Publication date: Available online 7 August 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Qijun Xu, Yu Lin, Zhen Xing, Tanhui Chen, Yingyan Zheng, Dairong Cao
ConclusionSingle transverse neck incision is an acceptable technique for modified radical neck dissection as it provides adequate surgical exposure for achieving optimal nodal clearance with little technical difficulty.
AbstractEarly oral squamous cell carcinoma (SCC) has a propensity for lymph-node metastasis. To address or not to address the neck electively during the ablative surgery has been an ongoing debate. In recent years, some practice-changing trial and systematic reviews have emerged and put to rest the discussion of elective neck dissection versus neck observation. Today elective neck is not a mere staging procedure. It has a definitive survival advantage, but the pathological basis of this advantage has not been elaborated. Understanding this could help answer some of the critical aspects of tumour spread.
For most people with atopic dermatitis, management of their skin disease includes years of continuous or intermittent use of topical medications. Counseling on that element of chronic disease management is a crucial part of physician visits for patients with atopic dermatitis. Inevitably, discussions about the long-term safety of patients ’ treatment plans are included and these discussions are usually based on little long-term evidence. Randomized clinical trials are often underpowered and too short to detect long-term, rare adverse events. Those clinical discussions became more nuanced with the introduction of the ...