Understanding the role of titin in dilated cardiomyopathy

Nonischemic dilated cardiomyopathy (NICM) is characterized by dilation and loss of function in one or both ventricles. NICM may be caused by a variety of primary or secondary conditions that affect the heart such as infiltrative causes, metabolic diseases, myocarditis, medications and many more. However, an estimated 50% of NICM are idiopathic or genetic [1], and are defined as dilated cardiomyopathies (DCM). There is a growing interest in the field of molecular genetics pertaining to DCM, and many genes have been identified that may contribute to phenotypically significant cardiomyopathy [2].

Source: International Journal of Cardiology - July 2, 2020 Category: Cardiology Authors: Ramone Eldemire, Matthew R.G. Taylor, Luisa Mestroni Tags: Editorial Source Type: research