Neuroinflammation drives APOE genotype-dependent differential expression of neprilysin

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by the deposition of amyloid-beta (A β) plaques and widespread neuroinflammation. While the cause of AD remains unknown, multiple factors likely contribute to the disease, including heart disease, diabetes, previous head injury, as well as a number of genetic determinants. Inheritance of the apolipoprotein (APOE) ε4 allele represents the strongest genetic risk factor for development of AD, driving pathogenesis and increasing overall disease severity.

Source: Journal of Neuroimmunology - July 2, 2020 Category: Allergy & Immunology Authors: David Graykowski, Kyle Kasparian, John Caniglia, Yelena Gritsaeva, Eiron Cudaback Source Type: research