Case Report: Dynamics of Acquired Fluoroquinolone Resistance under Standardized Short-Course Treatment of Multidrug-Resistant Tuberculosis.

We report a case of acquired fluoroquinolone (FQ) resistance under short-course multidrug-resistant tuberculosis (MDR-TB) treatment. The patient was managed at Kabutare hospital, one of the two specialized MDR-TB clinics in Rwanda. A low dose of moxifloxacin was used in the first three critical months. Acquired resistance was identified at the ninth month of treatment, 3 months after stopping kanamycin in a strain initially susceptible only to FQs, kanamycin, and clofazimine. Fluoroquinolone resistance was detected in the same month by deep sequencing as routinely used second-line probe assay and phenotypic drug susceptibility testing. High-dose FQ, preferably gatifloxacin, should be used to maximize effectiveness.
PMID: 32618257 [PubMed - as supplied by publisher]

Source: The American Journal of Tropical Medicine and Hygiene - July 4, 2020 Category: Tropical Medicine Authors: Semuto Ngabonziza JC, Van Deun A, Migambi P, Belamo NE, Théogène D, Habimana YM, Ushizimpumu B, Mulders W, Decroo T, Affolabi D, Supply P, de Jong BC, Rigouts L Tags: Am J Trop Med Hyg Source Type: research