Systemic Iron Overload Exacerbates Osteoarthritis in the Strain 13 Guinea Pig

Iron is emerging as a key player in aging-associated diseases due to its propensity for driving free radical formation. Studies examining the role of iron in the pathogenesis of primary osteoarthritis (OA) are limited. Our objective was to establish a direct relationship between excess iron and OA by administering iron dextran to a guinea pig strain with decreased propensity for developing OA.

Source: Osteoarthritis and Cartilage - July 2, 2020 Category: Rheumatology Authors: Lindsey H. Burton, Lauren B. Radakovich, Angela J. Marolf, Kelly S. Santangelo Source Type: research