Cholangiocarcinoma Metastasis to the Spine and Cranium.
Conclusion: To our knowledge, only 6 cases of cranial CCC have been reported, and only 2 reported mixed cranial/spinal involvement. We report a rare case of CCC metastasis to the spine and cranium that was treated with surgery, chemotherapy, and radiotherapy. CCC should be considered an exceedingly rare etiology with treatment options aimed solely at palliation. This case supplements the existing literature to inform medical and surgical decision-making. PMID: 32612476 [PubMed]
In this study, we found only minor ethnic differences in persistent pain. Similar living conditions and cultural features may explain these findings. PMID: 32780007 [PubMed - in process]
Publication date: September 2020Source: Biomedical Signal Processing and Control, Volume 62Author(s): Silvia Malavasi, Alessandro Bevilacqua, Giampaolo Gavelli, Domenico Barone
Publication date: September 2020Source: Biomedical Signal Processing and Control, Volume 62Author(s): Hong Chen, Xianpan Pan, Xuesong Lu, Qinlan Xie
Publication date: July 2020Source: Biomedical and Environmental Sciences, Volume 33, Issue 7Author(s): Qing Ming SHU, Xin Guo CHEN, Hong Ying ZHANG, Li Hong HUANG, Yong Liang ZHANG, Qing ZHANG
Publication date: July 2020Source: Biomedical and Environmental Sciences, Volume 33, Issue 7Author(s): Yong Pei YU, Jiang Ting CHEN, Zhi Wei JIANG, Ling WANG, Cheng Kai YU, Xiao Yan YAN, Chen YAO, Jie Lai XIA
Globoid cell leukodystrophy (GLD; Krabbe disease) is a progressive, incurable neurodegenerative disease caused by deficient activity of the hydrolytic enzyme galactosylceramidase (GALC). The ensuing cytotoxic accumulation of psychosine results in diffuse central and peripheral nervous system (CNS, PNS) demyelination. Presymptomatic hematopoietic stem cell transplantation (HSCT) is the only treatment for infantile-onset GLD; however, clinical outcomes of HSCT recipients often remain poor, and procedure-related morbidity is high. There are no effective therapies for symptomatic patients. Herein, we demonstrate in the natural...
NF-κB transcription factors, driven by the IRAK/IKK cascade, confer treatment resistance in pancreatic ductal adenocarcinoma (PDAC), a cancer characterized by near-universal KRAS mutation. Through reverse-phase protein array and RNA sequencing we discovered that IRAK4 also contributes substantially to MAPK activation in KRAS-mutant PDAC. IRAK4 ablation completely blocked RAS-induced transformation of human and murine cells. Mechanistically, expression of mutant KRAS stimulated an inflammatory, autocrine IL-1β signaling loop that activated IRAK4 and the MAPK pathway. Downstream of IRAK4, we uncovered TPL2 (also k...
Authors: Baek J, Jung SJ, Shim JS, Jeon YW, Seo E, Kim HC Abstract OBJECTIVES: We compared the associations of 3 computed tomography (CT)-based abdominal adiposity indexes with non-alcoholic fatty liver disease (NAFLD) among middle-aged Korean men and women. METHODS: The participants were 1366 men and 2480 women community-dwellers aged 30-64 years. Three abdominal adiposity indexes-visceral fat area (VFA), subcutaneous fat area (SFA), and visceral-to-subcutaneous fat ratio (VSR)-were calculated from abdominal CT scans. NAFLD was determined by calculating the Liver Fat Score from comorbidities and blood tests. A...
Publication date: Available online 23 July 2020Source: Reproductive BioMedicine OnlineAuthor(s): Antonio La Marca, Stefano Busani, Valeria Donno, Giovanni Guaraldi, Guido Ligabue, Massimo Girardis
Publication date: Available online 8 August 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Fatema Hamed Al Abri, Joshua Kanaabi Muliira, Huda Al Awaisi