Cancers, Vol. 12, Pages 1777: Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma

Cancers, Vol. 12, Pages 1777: Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12071777 Authors: Hyun Chang Yun-Gyoo Lee Yoon Ho Ko Jang Ho Cho Jong-Kwon Choi Keon Uk Park Eun Joo Kang Keun-Wook Lee Sun Min Lim Jin-Soo Kim Hyun Woo Lee Min Kyoung Kim In Gyu Hwang Sangwoo Kim Byung-Ho Nam Hye Ryun Kim Immune system dysfunction is associated with head and neck squamous cell carcinoma (HNSCC) development and progression and immune checkpoint inhibitors have demonstrated substantial survival benefits in platinum-refractory HNSCC; therefore, we examined the prognostic value of immune-related gene (IRG) expression in HNSCC. We analyzed the expression of 82 IRGs in 71 patients with HNSCC enrolled in a feasibility study for a prospective HNSCC biomarker-driven umbrella trial (Korean Cancer Study Group TRIUMPH study, NCT03292250). CD200R1 was identified as an independent prognostic factor and validated in GEO and TCGA database. CD2000R1 mRNA expression was found to be an independent favorable prognostic factor in patients with HNSCC. Moreover, CD200R1 was found to affect genes and pathways associated with the immune response, while seven differentially expressed genes (CD8A, DOK2, CX3CR1, TYROBP, CXCL9, CD300LF, IFNG) were associated with CD200R1 expression. Samples with higher CD200R1 expression displayed higher tumor-infiltrating immune cell counts both in silico and in histological...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research