Enhanced Prognostic Stratification of Neoadjuvant Treated Lung Squamous Cell Carcinoma by Computationally-Guided Tumor Regression Scoring

In a neoadjuvant setting, the administration of chemotherapy before surgery may result in significant reduction of the tumor burden, thus enabling radical resection in otherwise not operable patients. This treatment strategy has been shown to improve both overall (OS) [1] and recurrence-free survival (RFS) in resectable non-small cell lung carcinoma (NSCLC) [2]. Neoadjuvant chemotherapy induces distinctive morphological changes of both tumor and stromal compartments of solid carcinomas. This often results in significant reduction of tumor burden, which is accompanied by an increase of fibrotic stroma and necrosis as well as an increased infiltration by foamy cell macrophages [3].

Source: Lung Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ruben Casanova, Anne-Laure Leblond, Chengguang Wu, Martina Haberecker, Irene A. Burger, Alex Soltermann Source Type: research