Hyperboloid ‐Drum Microdisk Laser Biosensors for Ultrasensitive Detection of Human IgG

The new kind of microdisk lasers in a hyperboloid ‐drum (HD) shape is a combination of a dye‐doped photoresist and a silica microdisk. Such HD microdisk laser biosensors can achieve specific detection of human immunoglobulin G in phosphate‐buffered saline and artificial serum. The results from this study are approximately four orders of magni tude more sensitive than previous reports. AbstractWhispering gallery mode (WGM) microresonators have been used as optical sensors in fundamental research and practical applications. The majority of WGM sensors are passive resonators that require complex systems, thereby limiting their practicality. Active resonators enable the remote excitation and collection of WGM ‐modulated fluorescence spectra, without requiring complex systems, and can be used as alternatives to passive microresonators. This paper demonstrates an active microresonator, which is a microdisk laser in a hyperboloid‐drum (HD) shape. The HD microdisk lasers are a combination of a rhodamine B‐doped photoresist and a silica microdisk. These HD microdisk lasers can be utilized for the detection of label‐free biomolecules. The biomolecule concentration can be as low as 1 ag mL−1, whereas the theoretical detection limit of the biosensor for human IgG in phosphate buffer saline is 9 ag mL−1 (0.06 aM). Additionally, the biosensors are able to detect biomolecules in an artificial serum, with a theoretical detection limit of 9 ag mL−1 (0.06 aM). These results...

Source: Small - July 1, 2020 Category: Nanotechnology Authors: Zhihe Guo, Yingchun Qin, Peizong Chen, Jinliang Hu, Yi Zhou, Xuyang Zhao, Zhiran Liu, Yiyan Fei, Xiaoshun Jiang, Xiang Wu Tags: Full Paper Source Type: research