In Vivo Repeatedly Activated Persistent Luminescence Nanoparticles by Radiopharmaceuticals for Long ‐Lasting Tumor Optical Imaging

Radiopharmaceuticals (18F ‐FDG) with a short decay half‐life are used as the internal light source to in vivo excite Cr3+‐doped zinc gallate (ZGCs) for long‐lasting luminescence for multiple times. This strategy can provide tumor luminescence imaging with high sensitivity, high contrast, and long decay time at desired time, greatly benefiting image‐guided surgery in the future. AbstractPersistent luminescence nanoparticles (PLNPs) with rechargeable near ‐infrared afterglow properties attract much attention for tumor diagnosis in living animals since they can avoid tissue autofluorescence and greatly improve the signal‐to‐background ratio. Using UV, visible light, or X‐ray as excitation sources to power up persistent luminescence (PL) faces the challenges such as limited tissue penetration, inefficient charging capability, or tissue damage caused by irradiation. Here, it is proved that radiopharmaceuticals can efficiently excite ZnGa2O4:Cr3+ nanoparticles (ZGCs) for both fluorescence and afterglow luminescence via Cerenkov resonance energy transfer as well as ionizing radiation.18F ‐FDG, a clinically approved tumor‐imaging radiopharmaceutical with a short decay half‐life around 110 min, is successfully used as the internal light source to in vivo excite intravenously injected ZGCs for tumor luminescence imaging over 3 h. The luminescence with similar decay time can be re ‐obtained for multiple times upon injection of18F ‐FDG at any time needed with ...

Source: Small - July 1, 2020 Category: Nanotechnology Authors: Nian Liu, Junpeng Shi, Qiang Wang, Jingru Guo, Zhenyu Hou, Xinhui Su, Hongwu Zhang, Xiaolian Sun Tags: Full Paper Source Type: research