Syntheses of C2'-Fluorinated Analogs of Solamin.

Syntheses of C2'-Fluorinated Analogs of Solamin.
Chem Pharm Bull (Tokyo). 2020;68(7):675-678
Authors: Kojima N, Hayashi H, Iwasaki H, Yamashita M
Abstract
The details of the total syntheses of C2'-fluorinated analogs of solamin, an antitumor annonaceous acetogenin, are described. Fluorine was enantioselectively introduced at the C2'-position by organocatalytic α-fluorination of the aldehyde according to a previously reported method. C2'-fluorinated solamin and its C2'-diastereomer were synthesized by the Sonogashira coupling of a tetrahydrofuran fragment and fluorine-containing γ-lactone fragments.
PMID: 32612003 [PubMed - in process]

Source: Chemical and Pharmaceutical Bulletin - July 3, 2020 Category: Drugs & Pharmacology Authors: Kojima N, Hayashi H, Iwasaki H, Yamashita M Tags: Chem Pharm Bull (Tokyo) Source Type: research