CAR-T cell Therapy Related Neurotoxicity in Pediatric Acute Lymphoblastic Leukaemia (ALL): Spectrum of Imaging Findings

The emergence of CD19-targeted chimeric antigen receptor-T (CAR-T) cell therapy has created a new era in the management of pediatric patients with refractory B-cell malignancies such as B-cell acute lymphoblastic leukaemia (ALL). Immune effector cell-associated neurotoxicity syndrome (ICANS) is frequently encountered in the post infusion period of CD19-targeted CAR-T cell therapy and in some cases may be fatal. Knowledge related to the spectrum of imaging findings of CD19-targeted CAR-T cell therapy-related ICANS is however still very much lacking, underscoring the need for continued research in this area.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research