Independent, external validation of clinical prediction rules for the identification of extended-spectrum β-lactamase-producing Enterobacterales, University Hospital Basel, Switzerland, January 2010 to December 2016
ConclusionsApplying published prediction models to institutions these were not derived from, may result in substantial misclassification of patients considered as being at risk, potentially leading to wrong allocation of antibiotic treatment, negatively affecting patient outcomes and overall resistance rates in the long term. Future prediction models need to address differences in local epidemiology by allowing for customisation according to different settings.
Source: Eurosurveillance - Category: Infectious Diseases Authors: Isabelle Vock, Lisandra Aguilar-Bultet, Adrian Egli, Pranita D Tamma and Sarah Tschudin-Sutter Source Type: research