QSP ‐IO: A quantitative systems pharmacology toolbox for mechanistic multi‐scale modeling for immuno‐oncology applications

AbstractImmunotherapy has shown great potential in the treatment of cancer, however, only a fraction of patients respond to treatment and many experience autoimmune ‐related side effects. The pharmaceutical industry has relied on mathematical models to study the behavior of candidate drugs and more recently, complex, whole‐body, quantitative systems pharmacology (QSP) models have become increasingly popular for discovery and development. QSP modeling has th e potential to discover novel predictive biomarkers, as well as test the efficacy of treatment plans and combination therapies through virtual clinical trails. In this work, we present a QSP modeling platform for immuno‐oncology (IO) that incorporates detailed mechanisms for important immune inter actions. This modular platform allows for the construction of QSP models of IO with varying degrees of complexity based on the research questions. Finally, we demonstrate the use of the platform through two example applications of immune checkpoint therapy.
Source: CPT: Pharmacometrics and Systems Pharmacology - Category: Drugs & Pharmacology Authors: Tags: TUTORIAL Source Type: research