A Microfluidic Platform for Single Cell Fluorometric Granzyme B Profiling

Conclusion: As proof of concept, we have shown the capability of a microfluidic platform to measure GrB production through a single cell enzymatic activity assay. Our platform might be a promising tool for evaluating the sensitivity of immunotherapies and identifying specific T cell subset responsible for the anti-tumor response.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jonathan C. Briones, Wilfred V. Espulgar, Shohei Koyama, Hiroyuki Yoshikawa, JeongHoon Park, Yujiro Naito, Atsushi Kumanogoh, Eiichi Tamiya, Hyota Takamatsu, Masato Saito Tags: Research Paper Source Type: research