PET/MRI enables simultaneous in vivo quantification of β -cell mass and function

Conclusion: Simultaneous PET/MR imaging of the pancreas enabled the comprehensive in vivo quantification of β-cell function and mass using Mn and radiolabeled Ex4. Most important, our data revealed that only late time-point measurements reflect the Mn uptake in the islet β-cells, while early time points detect non-specific accumulation of Mn in the exocrine pancreas.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Filippo C. Michelotti, Gregory Bowden, Astrid K ü ppers, Lieke Joosten, Jonas Maczewsky, Volker Nischwitz, Gisela Drews, Andreas Maurer, Martin Gotthardt, Andreas M. Schmid, Bernd J. Pichler Tags: Research Paper Source Type: research