Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma

Conclusion: Our data support the function of miR-101 as a tumor suppressor in osteosarcoma via downregulation of BCL6. AD-MSC derived miR-101-enriched EVs represent a potential innovative therapy for metastatic osteosarcoma. EV-miR-101 also represents a promising circulating biomarker of osteosarcoma metastasis.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Kailiang Zhang, Chuan Dong, Ming Chen, Tongtao Yang, Xin Wang, Yongheng Gao, Lijuan Wang, Yanhua Wen, Guanyin Chen, Xinli Wang, Xiuchun Yu, Yinglong Zhang, Pingshan Wang, Mingfu Shang, Kang Han, Yong Zhou Tags: Research Paper Source Type: research