WNT signaling inducing activity in ascites predicts poor outcome in ovarian cancer

Conclusions: Our results highlight the role of WNT/PCP signaling in ovarian cancerogenesis, indicate a possible therapeutic potential of CK1 inhibitors for HGSC, and strongly suggest that the detection of WNT pathway inducing activity ascites (or WNT5A levels in ascites as a surrogate marker) could be a novel prognostic tool for HGSC patients.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Anna Kotrbov á , Petra Ovesn á , Tom á š Gybel', Tomasz Radaszkiewicz, Mark é ta Bedna ř í kov á , Jitka Hausnerov á , Eva Jand á kov á , Lubo š Min á ř , Igor Crha, V í t Weinberger, Lud ě k Z á vesk ý , V í t ě zslav Bryja, Vendula Tags: Research Paper Source Type: research