NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression

Conclusions: Our data revealed a novel signaling pathway, involving NFATc3, miR-153-3p, and Mfn1, which could be a therapeutic target for the prevention and treatment of cardiac hypertrophy.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Tao Wang, Mei Zhai, Sheng Xu, Murugavel Ponnusamy, Yan Huang, Cui-Yun Liu, Man Wang, Chan Shan, Pei-Pei Shan, Xiang-Qian Gao, Kai Wang, Xin-Zhe Chen, Jing Liu, Jing-Yi Xie, De-Yu Zhang, Lu-yu Zhou, Kun Wang Tags: Research Paper Source Type: research