Lipid oversupply induces CD36 sarcolemmal translocation via dual modulation of PKC ζ and TBC1D1: an early event prior to insulin resistance

Conclusion: Collectively, our study demonstrated exclusively that lipid oversupply induced CD36 sarcolemmal translocation via dual modulation of PKCζ and TBC1D1, which was as an early event prior to insulin resistance. The acquired data may provide potential therapy targets to prevent lipid oversupply-induced insulin resistance.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Bili Zhu, Ming-Yue Li, Quanming Lin, Zhicheng Liang, Qihang Xin, Menghuan Wang, Zhendan He, Xiaomei Wang, Xuli Wu, George G. Chen, Peter CY Tong, Weizhen Zhang, Li-Zhong Liu Tags: Research Paper Source Type: research