UCH-L1-mediated Down-regulation of Estrogen Receptor α Contributes to Insensitivity to Endocrine Therapy for Breast Cancer

Conclusions: Our results reveal an important role of UCH-L1 in modulating ERα status and demonstrate the involvement of UCH-L1-EGFR signaling pathway, suggesting that UCH-L1 may serve as a novel adjuvant target for treatment of hormone therapy-insensitive breast cancers. Targeting UCH-L1 to sensitize ER negative breast cancer to anti-estrogen therapy might represent a new therapeutic strategy that warrants further exploration.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Xi-Sha Chen, Kuan-Song Wang, Wei Guo, Lan-Ya Li, Pian Yu, Xin-Yuan Sun, Hai-Yan Wang, Yi-Di Guan, Yong-Guang Tao, Bo-Ni Ding, Ming-Zhu Yin, Xing-Cong Ren, Yi Zhang, Ce-Shi Chen, Yuan-Chao Ye, Jin-Ming Yang, Yan Cheng Tags: Research Paper Source Type: research