HIF-1 ɑ -regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/ β -catenin and Notch signaling

Conclusions: Our findings identified miR-1275 as a potential oncogene in LUAD that exerts its tumorigenic effect through co-activating Wnt/β-catenin and Notch signaling pathways. Thus, HIF-1ɑ-regulated miR-1275 might be a potential therapeutic target for LUAD.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Neng Jiang, Chang Zou, Ying Zhu, Yifeng Luo, Lili Chen, Yiyan Lei, Kejing Tang, Yu Sun, Wenhui Zhang, Shuhua Li, Qiong He, Jianwen Zhou, Yangshan Chen, Jiping Luo, Wenting Jiang, Zunfu Ke Tags: Research Paper Source Type: research