Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal M ü ller glia

Conclusions: Retinal permeabilisation via FUS in the presence of microbubbles is effective for delivering AAV2/8 across the inner blood-retinal-barrier, targeting Müller glia, which is less invasive than intravitreal injections that bypass the inner limiting membrane. However, implementing FUS in the clinic will require a comprehensive consideration of any off-target tropism of the AAV in peripheral organs, combined ideally, with the development of Müller glia-specific promoters.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yacine Touahri, Rajiv Dixit, Rikke Hahn Kofoed, Kristina Miloska, EunJee Park, Reza Raeisossadati, Kelly Markham-Coultes, Luke Ajay David, Hibo Rijal, Jiayi Zhao, Madelaine Lynch, Kullervo Hynynen, Isabelle Aubert, Carol Schuurmans Tags: Research Paper Source Type: research