Concurrent imaging of vascularization and metabolism in a mouse model of paraganglioma under anti-angiogenic treatment
Conclusion: These results demonstrate an adaptive resistance of Sdhb-/- tumors to six weeks of sunitinib treatment. Early metabolic changes and delayed vessel architecture changes were detectable and predictable in vivo early during anti-angiogenic treatment. Simultaneous metabolic, anatomical and functional imaging can monitor precisely the effects of anti-angiogenic treatment of tumors.
Source: Theranostics - Category: Molecular Biology Authors: Caterina Facchin, Mailyn Perez-Liva, Anikitos Garofalakis, Thomas Viel, Anais Certain, Daniel Balvay, Thulaciga Yoganathan, Justine Woszczyk, Kelly De Sousa, Joevin Sourdon, Jean Provost, Mickael Tanter, Charlotte Lussey-Lepoutre, Judith Favier, Bertrand Tags: Research Paper Source Type: research
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