Activation of microRNA-378a-3p biogenesis promotes hepatic secretion of VLDL and hyperlipidemia by modulating ApoB100-Sortilin1 axis

Conclusions: This study defines a novel pathway of E2F1-miR-378a-3p-SORT1-ApoB100 that controls levels of circulating VLDL/LDL cholesterol and triglycerides by modulating degradation and secretion of ApoB100, and suggests the use of miR-378a-3p as a potential therapeutic target for dyslipidemia.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Tianpeng Zhang, Hongtao Shi, Ningning Liu, Jing Tian, Xiaoling Zhao, Clifford J. Steer, Qinghua Han, Guisheng Song Tags: Research Paper Source Type: research