Myocardium-targeted transplantation of PHD2 shRNA-modified bone mesenchymal stem cells through ultrasound-targeted microbubble destruction protects the heart from acute myocardial infarction

Conclusions: The delivery of PHD2 shRNA-modified BMSCs by UTMD promoted grafted cell homing and activity, and increased myocardial angiogenesis in the infarcted heart, leading to improved cardiac function. This combination may provide a promising strategy for enhancing the effectiveness of stem cell therapy after acute myocardial infarction.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Zhenxing Sun, Yuji Xie, Robert J. Lee, Yihan Chen, Qiaofeng Jin, Qing Lv, Jing Wang, Yali Yang, Yuman Li, Yu Cai, Rui Wang, Zhengyang Han, Li Zhang, Mingxing Xie Tags: Research Paper Source Type: research