Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis

Conclusions: Dicer was downregulated in inflamed colon tissues before malignancy occurred. Decreased Dicer expression further exaggerated inflammation, which may promote carcinogenesis. Anastrozole, berberine, and pranoprofen alleviated colitis and colitis-associated tumorigenesis by promoting Dicer expression. Our study provides insight into potential colitis treatment and colitis-associated colon cancer prevention strategies.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Xiaoli Wu, Xiao Chen, Hui Liu, Zhong-Wei He, Zheng Wang, Lin-Jie Wei, Wei-Yun Wang, Shouhui Zhong, Qin He, Zhechao Zhang, Rongying Ou, Jian Gao, Youchun Lei, Wenjun Yang, Guanbin Song, Yi Jin, Lingli Zhou, Yunsheng Xu, Kai-Fu Tang Tags: Research Paper Source Type: research