89Zr-PET imaging of DNA double-strand breaks for the early monitoring of response following α - and β -particle radioimmunotherapy in a mouse model of pancreatic ductal adenocarcinoma

Conclusions: PET imaging studies with [89Zr]Zr-DFO-anti-γH2AX-TAT following α- and β-particle PRIT in a BxPC3 PDAC subcutaneous xenograft mouse model allowed the monitoring of tumor radiobiological response to treatment.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Sophie Poty, Komal Mandleywala, Edward O'Neill, James C. Knight, Bart Cornelissen, Jason S. Lewis Tags: Research Paper Source Type: research