In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy

Conclusions: This study is the first to report the real-time noninvasive tracking of the progression of ZIKV invading immune-sheltered tissues and propagating vertically during pregnancy. The results demonstrate that ZIKV-Nluc represents a powerful tool for the study of the replication, dissemination, pathogenesis, and treatment of ZIKV in vitro and in vivo.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Ting Wang, Penghui Li, Yuan Zhang, Yan Liu, Zhongyuan Tan, Jianhong Sun, Xianliang Ke, Yuanjiu Miao, Dan Luo, Qinxue Hu, Fuqiang Xu, Hanzhong Wang, Zhenhua Zheng Tags: Research Paper Source Type: research