Exercise protects proliferative muscle satellite cells against exhaustion via the Igfbp7-Akt-mTOR axis

Conclusions: The findings of our study show that exercise protects proliferative SCs against exhaustion via the Igfbp7-Akt-mTOR axis. These findings establish a link between mechanical signaling, mitochondrial metabolism, epigenetic modification, and stem cell fate decisions; thus, present potential therapeutic targets for muscle diseases correlated with SC exhaustion.

http://www.thno.org/v10p6448.htm

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Zhe Chen, Lei Li, Weiru Wu, Zhilong Liu, Yongxiu Huang, Li Yang, Qing Luo, Jieping Chen, Yu Hou, Guanbin Song Tags: Research Paper Source Type: research