HDAC6-specific inhibitor suppresses Th17 cell function via the HIF-1 α pathway in acute lung allograft rejection in mice

Conclusion: These findings suggest that Tubastatin A downregulates Th17 cell function and suppresses acute lung allograft rejection, at least partially, via the HIF-1α/ RORγt pathway.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Wenyong Zhou, Jun Yang, Gaowa Saren, Heng Zhao, Kejian Cao, Shijie Fu, Xufeng Pan, Huijun Zhang, An Wang, Xiaofeng Chen Tags: Research Paper Source Type: research