Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility

Zygotic cleavage failure (ZCF) is a unique early embryonic phenotype resulting in female infertility and recurrent failure of in  vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). With this phenotype, morphologically normal oocytes can be retrieved and successfully fertilized, but they fail to undergo cleavage. Until now, whether this phenotype has a Mendelian inheritance pattern and which underlying genetic factors play a role in its development remained to be elucidated.

Source: The American Journal of Human Genetics - June 3, 2020 Category: Genetics & Stem Cells Authors: Wei Zheng, Zhou Zhou, Qianqian Sha, Xiangli Niu, Xiaoxi Sun, Juanzi Shi, Lei Zhao, Shuoping Zhang, Jing Dai, Sufen Cai, Fei Meng, Liang Hu, Fei Gong, Xiaoran Li, Jing Fu, Rong Shi, Guangxiu Lu, Biaobang Chen, Hengyu Fan, Lei Wang, Ge Lin, Qing Sang Tags: Article Source Type: research