Performance of immune-based and microbiological tests in children with tuberculosis meningitis in Europe: a multicentre Paediatric Tuberculosis Network European Trials Group (ptbnet) study

Conclusions Existing immunological and microbiological TB tests have suboptimal sensitivity in children with TBM, with each test producing false-negative results in a substantial proportion of patients. Combining immune-based tests with CSF culture and CSF PCR results in considerably higher positive diagnostic yields, and should therefore be standard clinical practice in high-resource settings.

http://erj.ersjournals.com/cgi/content/short/56/1/1902004?rss=1

Source: European Respiratory Journal - July 1, 2020 Category: Respiratory Medicine Authors: Basu Roy, R., Thee, S., Blazquez-Gamero, D., Falcon-Neyra, L., Neth, O., Noguera-Julian, A., Lillo, C., Galli, L., Venturini, E., Buonsenso, D., Götzinger, F., Martinez-Alier, N., Velizarova, S., Brinkmann, F., Welch, S. B., Tsolia, M., Santiago-G Tags: Original Articles: Tuberculosis and paediatrics Source Type: research