Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma

This study delineates a novel mast cell–ASM interaction and TRPV4 as a driver of IgE-independent mast cell-dependent bronchospasm.

Source: European Respiratory Journal - July 1, 2020 Category: Respiratory Medicine Authors: Bonvini, S. J., Birrell, M. A., Dubuis, E., Adcock, J. J., Wortley, M. A., Flajolet, P., Bradding, P., Belvisi, M. G. Tags: Lung biology and experimental studies, Asthma and allergy Original Articles: Asthma and basic science Source Type: research