Fibrinogen Monitoring during Catheter-Directed Thrombolysis for Pulmonary Embolism: Can It Be Cleaved from Our Practice?

In this issue of the Journal of Vascular Interventional Radiology, Graif et  al retrospectively analyzed initial, nadir, and final fibrinogen levels during tissue plasminogen activator (TPA) infusion in 147 patients treated with catheter-directed thrombolysis (CDT) for acute massive or submassive pulmonary embolism (PE). Their main purpose was to identify relationships bet ween (i) TPA infusion and fibrinogen levels and (ii) bleeding and fibrinogen levels. They secondarily sought correlations between CDT technique (ultrasound [US]-assisted vs conventional) and fibrinogen levels and between concomitant anticoagulation (enoxaparin vs unfractionated heparin) and fibrinog en levels.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Commentary Source Type: research