Desirability Function Approach for Development of a Thermosensitive and Bioadhesive Nanotransfersome-Hydrogel Hybrid System for Enhanced Skin Bioavailability and Antibacterial Activity of Cephalexin.

Desirability Function Approach for Development of a Thermosensitive and Bioadhesive Nanotransfersome-Hydrogel Hybrid System for Enhanced Skin Bioavailability and Antibacterial Activity of Cephalexin. Drug Dev Ind Pharm. 2020 Jun 29;:1-42 Authors: Salatin S, Jelvehgari M Abstract Cellulitis is a common bacterial infection of the skin and soft tissues immediately beneath the skin. Despite the successful use of antibiotics in the treatment of infectious diseases, bacterial infections continue to impose significant global health challenges because of the rapid emergence of antibiotic resistance. The aim of this work was to develop an in-situ hydrogel forming system containing highly permeable cephalexin-loaded nanotransfersomes (NTs), suitable for antibacterial drug delivery. Response surface design was applied for the optimization of NTs. Cephalexin NTs were prepared using thin-film hydration method and then embedded into a 3D hydrogel network. The in vitro antibacterial activity of the optimized NTs was assayed against indicator bacteria of Staphylococcus aureus (S. aureus). The drug permeation was evaluated using an ex vivo rat skin model. The in vivo efficacy of the cephalexin NT-hydrogel was also determined against rat skin infection. The resulting data verified the formation of NTs, the size of which was approximately 192 nm. The cephalexin NTs exhibited higher antibacterial activity against S. aureus as compared to the untreated...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research