Aberrant CDK9 expression within chordoma tissues and the therapeutic potential of a selective CDK9 inhibitor LDC000067

Conclusion: We demonstrate that CDK9 expression in chordoma correlates with patient outcome, and, when inhibited, chordoma cell growth and proliferation significantly decreases. Taken together, these results support CDK9 as an emerging potential target in chordoma therapy.

Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Shen Shen, Dylan C. Dean, Zujiang Yu, Francis Hornicek, Quancheng Kan, Zhenfeng Duan Tags: Research Paper Source Type: research