Efficacy of EGFR-TKIs with or without angiogenesis inhibitors in advanced non-small-cell lung cancer: A systematic review and meta-analysis

In the present study, we evaluated the efficacy and safety of epidermal growth factor receptor tyrosine kinases (EGFR-TKIs) combined with or without angiogenesis inhibitors in advanced non-small-cell lung cancer (NSCLC). We searched published randomized controlled trials (RCTs) comparing EGFR-TKIs with and without angiogenesis inhibitors for the treatment of advanced NSCLC. PubMed, EMBASE, PMC, the American Society of Clinical Oncology (ASCO) and the European Society of Medical Oncology (ESMO) databases were searched. The extracted data on progression-free survival (PFS) and overall survival (OS) were measured in terms of hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). In addition, odds ratios (ORs) and corresponding 95% CIs were pooled for objective response rate (ORR) and disease control rate (DCR). Risk ratios (RRs) and corresponding 95% CIs were pooled for risk of adverse events (AEs). EGFR-TKIs combined with angiogenesis inhibitors showed significant improvements in PFS (HR 0.72, 95% CI 0.61-0.84, P
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research

Related Links:

SUPPLEMENTS could be used to improve the health of your heart, as well as to protect against high blood pressure symptoms and signs. Add these cheap garlic capsules to your diet to lower your risk of heart problems, including heart attacks and heart disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Those suffering from cancer, heart conditions, strokes, diabetes and lung disease are among the worst affected by delays to their diagnosis and care, a survey of senior doctors reveals.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
HIGH blood pressure is a largely symptomless silent killer. If a person ignores their blood pressure because they think a certain symptom will alert them to the problem, they are taking a dangerous chance with their life. There are two waring signs which lay in a person's face.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The objective of this study was to report the incidence of alopecia arising in patients treated with vismodegib, assessing its characteristics, grade of severity, and time of onset.Skin Appendage Disord
Source: Skin Appendage Disorders - Category: Dermatology Source Type: research
CONCLUSIONS: Surprisingly, the DCR registered fewer patients in 2013-2014 than the DLCR, even though they employ the same primary data source. The agreement between the DCR and the DLCR was 87%; this may be increased to 95% if patients who seemed to meet the inclusion criteria of the other register were also included. The discrepancies found were mainly due to different definitions of dates of diagnosis, registrations probably missed by the algorithms and possible registration errors. Discrepancies resulted in a significant difference in MRR, but not in 1y-RS. FUNDING: none. TRIAL REGISTRATION: not relevant. PM...
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
CONCLUSIONS: Most women did not experience any improvement in their symptoms over time, and no association was found between lack of symptom improvement and believing that the HPV vaccine was causing the symptoms. FUNDING: funded by the Danish Cancer Society. TRIAL REGISTRATION: not relevant. PMID: 32741432 [PubMed - in process]
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
Conclusions: In our large cohort of CAS patients, coexistent UIAs are not uncommon. Stenting of a carotid artery in the presence of coexistent UIAs could be conducted safely. Together with 3-month dual antiplatelet therapy, CAS did not increase the rupture risk of the coexistent UIAs within 3 months.Cerebrovasc Dis
Source: Cerebrovascular Diseases - Category: Neurology Source Type: research
Date: Friday, 09 25, 2020; Speaker: Dr. Dauod Meerzaman; Building: Building 10 (Clinical Center); This class is presented as a webinar only; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Wednesday, 05 12, 2021; Speaker: Christine Ambrosone, Ph.D., University of Buffalo; 6100 Executive Boulevard; 3rd Floor Conference Room
Source: NIH Calendar of Events - Category: American Health Source Type: events
Liver Cancer 2020;9:477 –478
Source: Liver Cancer - Category: Cancer & Oncology Source Type: research
More News: Cancer | Cancer & Oncology | Databases & Libraries | Dermatitis | Dermatology | Hypertension | Lung Cancer | Non-Small Cell Lung Cancer | Study | Thrombocytopenia