DNA sensors, crucial receptors to resist pathogens, are deregulated in colorectal cancer and associated with initiation and progression of the disease

Conclusions: Our study revealed that the expression of multiple DNA sensors was deregulated in CRC and might be involved in tumor development. More importantly, the study identified that, among all these DNA sensors, AIM2, DAI, and DDX60 could be potentially critical for diagnosis, prognosis, and therapy of CRC and deserve further investigation.

Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Liangmei He, Yuxia Liu, Weiling Lai, Hongbo Tian, Lingxia Chen, Lu Xie, Zhiping Liu Tags: Research Paper Source Type: research