The somatic mutation landscape of Chinese Colorectal Cancer

In this study, we have performed whole exome-sequencing analysis of 63 CRC cases. We found that Chinese CRC were hypermutated, which were enriched in ECM-receptor interaction, antigen processing and presentation, and focal adhesion. Analysis with clinical characteristics indicated that the deficiency of CRC driver gene, FCGBP and NBPF1 conferred CRC development and was showed worse survival rates, which could be the novel regulators and, diagnostic and prognostic biomarkers for Chinese CRC. Taken together, the application of whole exome-sequencing unveiled previously unsuspected somatic mutation landscape in Chinese CRCs, which may expand the understanding of disease mechanisms and provide an alternative personalized treatment for Chinese CRC patients.

Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Rong Ma, Changwen Jing, Yuan Zhang, Haixia Cao, Siwen Liu, Zhuo Wang, Dan Chen, Junying Zhang, Yang Wu, Jianzhong Wu, Jifeng Feng Tags: Research Paper Source Type: research