Macrovascular Endothelial Cells Enhance the Motility of Liver Cancer Cells by Up-regulation of MMP-3, Activation of Integrin/FAK Signaling Pathway and Induction of Non-classical Epithelial-mesenchymal Transition

Conclusion: HUVEC may provide an easy-to-adhere roadbed for liver cancer cells invasion of blood vessels by altering extracellular matrix (ECM), activating integrins/FAK pathway and inducing non-classical EMT. The effect of HUVEC-CM on cell viability was cancer cell type dependent. It is a meaningful glance at the mechsanism of PVTT.

Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Song-Ming Ding, Ai-Li Lu, Jian-Fang Lu, Xu-Liang Chen, Muhammad Ibrahim Alhadi Edoo, Lin Zhou, Hai-Yang Xie, Shu-Sen Zheng, Qi-Yong Li Tags: Research Paper Source Type: research